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Table 2 Epidemiological parameters considered in the analytic model

From: Cost-effectiveness of diagnostic for malaria in Extra-Amazon Region, Brazil

Parameter Base-case value Variation values Information sources
Prevalence of malaria among febrile patients seeking diagnosis 0.467 0.560 e 0.373 Base-case: Ministry of Health
    Variation: 20% above and below the base-case.
Proportion of malaria cases due to Plasmodium vivax 0.713 0.856-0.570 Base-case: Ministry of Health
    Variation: 20% above and below the base-case.
Proportion of malaria cases due to Plasmodium falciparum 0.287 0.344-0.230 Base-case: Ministry of Health
    Variation: 20% above and below the base-case.
Sensitivity of microscopy for Plasmodium vivax 0.950 0.717 Base-case: Ohrt e et al., 2002 - Variation: Andrade e et al., 2010.
Specificity of microscopy for Plasmodium vivax 1.000 0.950 Base-case: Haghdoost et al., 2006; Variation: Haghdoost et al., 2006.
Sensitivity of microscopy for Plasmodium falciparum 0.976 0.757 Base-case: Alam et al., 2011; Variation: Andrade et al., 2010.
Specificity of microscopy for Plasmodium falciparum 1.000 0.932 Base-case: Andrade et al., 2010; Variation: Alam e et al., 2011;
Sensitivity of CareStart™ for Plasmodium vivax 0.953 0.711-1.000 Base-case: Mekonnen et al., 2010; Variation: Upper value: Sharew e et al., 2009. Lower value: Ashley e et al., 2009.
Specificity of CareStart™ for Plasmodium vivax 1.000 0.919 Base-case: Mekonnen e et al., 2010; Variation: Ratsimbasoa e et al., 2007.
Sensitivity of CareStart™ for Plasmodium falciparum 0.964 0.854-1.000 Base-case: Mekonnen et al., 2010; Variation: Upper value: Sharew e et al., 2009. Lower value: Ashley e et al., 2009.
Specificity of CareStart™ for Plasmodium falciparum 1.000 0.881 Base-case: Mekonnen et al., 2010; Variation: Ratsimbasoa e et al., 2007.
Sensitivity of First Response Malaria Combo™ for Plasmodium vivax 0.842 0.721-0.925 Base-case: Singh et al., 2010; Variation: Singh et al., 2010
Specificity of First Response Malaria Combo™ for Plasmodium vivax 0.940 0.900 – 0.982 Base-case: Bharti e et al., 2008; Variation: Upper value: Singh et al., 2010. Lower value: Bharti et al., 2008.
Sensitivity of First Response Malaria Combo™ for Plasmodium falciparum 0.960 0.880-0.990 Base-case: Bharti e et al., 2008; Variation: Bharti e et al., 2008.
Specificity of First Response Malaria Combo™ for Plasmodium falciparum 0.950 0.756-0.970 Base-case: Bharti et al.,2008; Variation: Upper value: Bharti et al., 2008. Lower value: Singh et al., 2010.
Sensitivity of Parascreen™ for Plasmodium vivax 0.772 0.642-0.873 Base-case: Singh e et al., 2010; Variation: Singh e et al., 2010.
Specificity of Parascreen™ for Plasmodium vivax 0.981 0.959-0.993 Base-case: Singh et al., 2010; Variation: Singh et al., 2010.
Sensitivity of Parascreen™ for Plasmodium falciparum 0.940 0.885-0.974 Base-case: Singh et al., 2010; Variation: Singh et al., 2010.
Specificity of Parascreen™ for Plasmodium falciparum 0.720 0.658-0.776 Base-case: Singh et al., 2010; Variation: Singh et al., 2010.
Sensitivity of BinaxNOW™ for Plasmodium vivax 0.873 0.729-0.930 Base-case: Wongsrichanalai et al., 2003; Variation: Upper value: Wongsrichanalai et al., 2003. Lower value: Pabón et al., 2007.
Specificity of BinaxNOW™ for Plasmodium vivax 0.977 0.995-1.00 Base-case: Wongsrichanalai et al., 2003; Variation: Pabón e et al., 2007.
Sensitivity of BinaxNOW™ for Plasmodium falciparum 1.000 0.520-0.960 Base-case: Wongsrichanalai et al., 2003; Variation: Upper value: Farcas et al., 2003. Lower value: Pabón et al., 2007.
Specificity of BinaxNOW™ for Plasmodium falciparum 0.962 0.920-0.980 Base-case: Wongsrichanalai et al., 2003; Variation: Wongsrichanalai et al., 2003.
Sensitivity of SD Bioline FK60 (PF/Pan)™ for Plasmodium vivax 0.710 0.636(0.424-0.815) Base-case: Vas Dev, 2004. Variation: Ratsimbasoa, 2008 (1)
Specificity of SD Bioline FK60 (PF/Pan)™ for Plasmodium vivax 1.000 0.989(0.946-0.999) Base-case: Vas Dev, 2004. Variation: Ratsimbasoa, 2008
Sensitivity of SD Bioline FK60 (PF/Pan)™ for Plasmodium falciparum 1.000 0.929 (0.889-0.971) Base-case: Vas Dev, 2004. Variation: Ratsimbasoa, 2008
Specificity of SD Bioline FK60 (PF/Pan)™ for Plasmodium falciparum 1.000 0.989 (0.946-0.999) Caso-base: Vas Dev, 2004. Variação: Ratsimbasoa, 2008
  1. Extra-Amazon Region, Brazil, 2010.
  2. Note: (1) Exception: The article by Ratsimbasoa (2008) used a combination of PCR and thick smear as the gold standard.