Cost-effectiveness of diagnostic for malaria in Extra-Amazon Region, Brazil

de Oliveira, Maria Regina F; Giozza, Silvana P; Peixoto, Henry M; Romero, Gustavo AS

doi:10.1186/1475-2875-11-390

Malaria Journal

Table 2 Epidemiological parameters considered in the analytic model

From: Cost-effectiveness of diagnostic for malaria in Extra-Amazon Region, Brazil

Parameter	Base-case value	Variation values	Information sources
Prevalence of malaria among febrile patients seeking diagnosis	0.467	0.560 e 0.373	Base-case: Ministry of Health
			Variation: 20% above and below the base-case.
Proportion of malaria cases due to Plasmodium vivax	0.713	0.856-0.570	Base-case: Ministry of Health
			Variation: 20% above and below the base-case.
Proportion of malaria cases due to Plasmodium falciparum	0.287	0.344-0.230	Base-case: Ministry of Health
			Variation: 20% above and below the base-case.
Sensitivity of microscopy for Plasmodium vivax	0.950	0.717	Base-case: Ohrt e et al., 2002 - Variation: Andrade e et al., 2010.
Specificity of microscopy for Plasmodium vivax	1.000	0.950	Base-case: Haghdoost et al., 2006; Variation: Haghdoost et al., 2006.
Sensitivity of microscopy for Plasmodium falciparum	0.976	0.757	Base-case: Alam et al., 2011; Variation: Andrade et al., 2010.
Specificity of microscopy for Plasmodium falciparum	1.000	0.932	Base-case: Andrade et al., 2010; Variation: Alam e et al., 2011;
Sensitivity of CareStart™ for Plasmodium vivax	0.953	0.711-1.000	Base-case: Mekonnen et al., 2010; Variation: Upper value: Sharew e et al., 2009. Lower value: Ashley e et al., 2009.
Specificity of CareStart™ for Plasmodium vivax	1.000	0.919	Base-case: Mekonnen e et al., 2010; Variation: Ratsimbasoa e et al., 2007.
Sensitivity of CareStart™ for Plasmodium falciparum	0.964	0.854-1.000	Base-case: Mekonnen et al., 2010; Variation: Upper value: Sharew e et al., 2009. Lower value: Ashley e et al., 2009.
Specificity of CareStart™ for Plasmodium falciparum	1.000	0.881	Base-case: Mekonnen et al., 2010; Variation: Ratsimbasoa e et al., 2007.
Sensitivity of First Response Malaria Combo™ for Plasmodium vivax	0.842	0.721-0.925	Base-case: Singh et al., 2010; Variation: Singh et al., 2010
Specificity of First Response Malaria Combo™ for Plasmodium vivax	0.940	0.900 – 0.982	Base-case: Bharti e et al., 2008; Variation: Upper value: Singh et al., 2010. Lower value: Bharti et al., 2008.
Sensitivity of First Response Malaria Combo™ for Plasmodium falciparum	0.960	0.880-0.990	Base-case: Bharti e et al., 2008; Variation: Bharti e et al., 2008.
Specificity of First Response Malaria Combo™ for Plasmodium falciparum	0.950	0.756-0.970	Base-case: Bharti et al.,2008; Variation: Upper value: Bharti et al., 2008. Lower value: Singh et al., 2010.
Sensitivity of Parascreen™ for Plasmodium vivax	0.772	0.642-0.873	Base-case: Singh e et al., 2010; Variation: Singh e et al., 2010.
Specificity of Parascreen™ for Plasmodium vivax	0.981	0.959-0.993	Base-case: Singh et al., 2010; Variation: Singh et al., 2010.
Sensitivity of Parascreen™ for Plasmodium falciparum	0.940	0.885-0.974	Base-case: Singh et al., 2010; Variation: Singh et al., 2010.
Specificity of Parascreen™ for Plasmodium falciparum	0.720	0.658-0.776	Base-case: Singh et al., 2010; Variation: Singh et al., 2010.
Sensitivity of BinaxNOW™ for Plasmodium vivax	0.873	0.729-0.930	Base-case: Wongsrichanalai et al., 2003; Variation: Upper value: Wongsrichanalai et al., 2003. Lower value: Pabón et al., 2007.
Specificity of BinaxNOW™ for Plasmodium vivax	0.977	0.995-1.00	Base-case: Wongsrichanalai et al., 2003; Variation: Pabón e et al., 2007.
Sensitivity of BinaxNOW™ for Plasmodium falciparum	1.000	0.520-0.960	Base-case: Wongsrichanalai et al., 2003; Variation: Upper value: Farcas et al., 2003. Lower value: Pabón et al., 2007.
Specificity of BinaxNOW™ for Plasmodium falciparum	0.962	0.920-0.980	Base-case: Wongsrichanalai et al., 2003; Variation: Wongsrichanalai et al., 2003.
Sensitivity of SD Bioline FK60 (PF/Pan)™ for Plasmodium vivax	0.710	0.636(0.424-0.815)	Base-case: Vas Dev, 2004. Variation: Ratsimbasoa, 2008 ⁽¹⁾
Specificity of SD Bioline FK60 (PF/Pan)™ for Plasmodium vivax	1.000	0.989(0.946-0.999)	Base-case: Vas Dev, 2004. Variation: Ratsimbasoa, 2008
Sensitivity of SD Bioline FK60 (PF/Pan)™ for Plasmodium falciparum	1.000	0.929 (0.889-0.971)	Base-case: Vas Dev, 2004. Variation: Ratsimbasoa, 2008
Specificity of SD Bioline FK60 (PF/Pan)™ for Plasmodium falciparum	1.000	0.989 (0.946-0.999)	Caso-base: Vas Dev, 2004. Variação: Ratsimbasoa, 2008

Extra-Amazon Region, Brazil, 2010.
Note: ⁽¹⁾ Exception: The article by Ratsimbasoa (2008) used a combination of PCR and thick smear as the gold standard.

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ISSN: 1475-2875

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