The visual predictive check of the final piperaquine model.. The circles represent the observations, the solid line represents the 5th, 50th and 95th percentile of the observed data. The shaded areas represent the simulated 95% confidence interval around the 5th, 50th and 95th percentile. Concentrations were transformed to their logarithms (base 10). Predicted performance during the three first days is inserted in the top right corner.