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Table 1 Admission demographic data of study population

From: A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan

 

Non-pregnant women

Pregnant women

P-value

 

Median (Range)

Median (Range)

 

Number of patients

12

12

-

Daily piperaquine (phosphate) dose (mg/kg)

18.1 (15.1-24.2)

17.6 (13.6-21.7)

0.884

Daily piperaquine (base) dose (mg/kg)

10.5 (8.71-13.9)

10.2 (7.83-12.5)

0.884

Age (years)

21.0 (16.0-43.0)

26.0 (18.0-33.0)

0.977

Body weight (kg)

53.0 (44.0-81.0)

59.0 (50.0-72.0)

0.544

Height (cm)

163 (150–174)

166 (150–174)

0.908

Estimated gestational age (weeks)

-

32.0 (15.3–40.1)

-

Parasitemia (parasites/μL)

13200 (936–68700)

12900 (624–118000)

0.488

Days of fever

2.5 (1–6)

3 (1–6)

0.095

Fever (°C)

38.3 (36.7-40.0)

38.2 (36.6-39.9)

0.795

Haemoglobin (g/dL)

8.70 (7.60-11.5)

9.65 (8.00-12.0)

0.099

Urea (mg/dL)

26.0 (24.0-28.0)

25.0 (24.0-28.0)

0.036

Serum glutamic pyruvic transaminase (IU/L)

5.00 (2.00-10.0)

4.50 (2.00-9.00)

0.445

Serum glutamic oxaloacetic transaminase (IU/L)

13.5 (2.00-18.0)

13.0 (3.00-21.0)

0.727

  1. The p-values are calculated using the Mann–Whitney U-test.