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Table 4 A literature comparison of the pharmacokinetic properties of piperaquine

From: A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan

Study population Age (years) Study size (Males/Females) t1/2 (days) CL/F (L/h/kg) VD/F (L/kg) Method Reference
Piperaquine pharmacokinetics in pregnant women
Pregnant Sudanese women with uncomplicated P. falciparum malaria 18-33 12 (0/12) 22.1 0.678 384 Pop PK This study
Pregnant Thai and Karen women with uncomplicated P. falciparum malaria 18-43 24 (0/24) 17.5 1.28 529 Pop PK [19]
Piperaquine pharmacokinetics in non-pregnant populations
Non-pregnant Sudanese women with uncomplicated P. falciparum malaria 16-43 12 (0/12) 25.7 0.739 446 Pop PK This study
Non-pregnant Thai and Karen women with uncomplicated P. falciparum malaria 18-45 24 (0/24) 24.0 1.32 829 Pop PK [19]
Non-pregnant Thai and Karen males and females with uncomplicated P. falciparum malaria 6-52 98 (59/39) 27.8 1.37 874 Pop PK [17]
Non-pregnant Cambodian males and females with uncomplicated P. falciparum malaria 30±13† 38 (20/18) 22.6 0.900 574 Pop PK [14]
Healthy Vietnamese males 21-45 12 (12/0) 23.0 1.82 194 Pop PK [15]
Piperaquine pharmacokinetics in children
Children in Papua New Guinea with uncomplicated P. falciparum and P. vivax malaria 7.1 ±1.5† 12 (8/4) 21.3 0.573* 385* Pop PK [54]
Children in Burkina Faso with uncomplicated P. falciparum malaria 2-10 236 (131/105) 23.2 0.417 214 Pop PK [20]
Children in Papua New Guinea with uncomplicated P. falciparum, P. vivax and P. malariae malaria 6.9 ±1.4† 22 (17/5) 17.2 0.850 431 Pop PK [53]
Cambodian children with uncomplicated P. falciparum malaria 7±2† 47 (26/21) 13.5 1.85 614 Pop PK [14]
Influence of diet on piperaquine pharmacokinetics
Fasting non-pregnant Thai and Karen males and females with uncomplicated P. falciparum malaria 18-55 15 (13/2) 17.5 1.19 700 NCA [18]
Fed non-pregnant Thai and Karen males and females with uncomplicated P. falciparum malaria 19-41 15 (13/2) 21.4 1.01 769 NCA [18]
Healthy Caucasian males and non-pregnant women, low fat meal 19-42 8 (4/4) 20.3* 1.14* 716* NCA [16]
Healthy Caucasian males and non-pregnant women, high fat meal 19-42 8 (4/4) 20.9* 0.60* 365* NCA [16]
  1. CL/F is the apparent elimination clearance, t1/2 is the elimination half-life, VD/F is the apparent volume of distribution, Pop PK represents a population pharmacokinetic analysis and NCA represents a non-compartmental analysis. Age is given as a range or (†) as mean ± standard deviation. Other parameters are given as median or as mean when indicated (*).