Table 4 A literature comparison of the pharmacokinetic properties of piperaquine

Piperaquine pharmacokinetics in pregnant women

Pregnant Sudanese women with uncomplicated P. falciparum malaria

18-33

22.1

0.678

384

Pop PK

This study

Pregnant Thai and Karen women with uncomplicated P. falciparum malaria

18-43

17.5

1.28

529

Pop PK

[19]

Piperaquine pharmacokinetics in non-pregnant populations

Non-pregnant Sudanese women with uncomplicated P. falciparum malaria

16-43

25.7

0.739

446

Pop PK

This study

Non-pregnant Thai and Karen women with uncomplicated P. falciparum malaria

18-45

24.0

1.32

829

Pop PK

[19]

Non-pregnant Thai and Karen males and females with uncomplicated P. falciparum malaria

6-52

27.8

1.37

874

Pop PK

[17]

Non-pregnant Cambodian males and females with uncomplicated P. falciparum malaria

30±13†

22.6

0.900

574

Pop PK

[14]

Healthy Vietnamese males

21-45

23.0

1.82

194

Pop PK

[15]

Piperaquine pharmacokinetics in children

Children in Papua New Guinea with uncomplicated P. falciparum and P. vivax malaria

7.1 ±1.5†

21.3

0.573*

385*

Pop PK

[54]

Children in Burkina Faso with uncomplicated P. falciparum malaria

2-10

23.2

0.417

214

Pop PK

[20]

Children in Papua New Guinea with uncomplicated P. falciparum, P. vivax and P. malariae malaria

6.9 ±1.4†

17.2

0.850

431

Pop PK

[53]

Cambodian children with uncomplicated P. falciparum malaria

7±2†

13.5

1.85

614

Pop PK

[14]

Influence of diet on piperaquine pharmacokinetics

Fasting non-pregnant Thai and Karen males and females with uncomplicated P. falciparum malaria

18-55

17.5

1.19

700

NCA

[18]

Fed non-pregnant Thai and Karen males and females with uncomplicated P. falciparum malaria

19-41

21.4

1.01

769

NCA

[18]

Healthy Caucasian males and non-pregnant women, low fat meal

19-42

20.3*

1.14*

716*

NCA

[16]

Healthy Caucasian males and non-pregnant women, high fat meal

19-42

20.9*

0.60*

365*

NCA

[16]