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Figure 4 | Malaria Journal

Figure 4

From: Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

Figure 4

Studies of 51Cr labelled red cell survival in healthy adult hemizygous male volunteers with the A-variant of G6PD deficiency exposed to different dose regimens of primaquine in studies conducted by the University of Chicago-Army Medical Research Unit at the Illinois State penitentiary (Stateville) from 1950 to 1962. Daily doses are shown within the range of red cell survivals that resulted. Daily administration of 45 mg base primaquine was considered to result in “dangerous haemolytic anaemia”, daily administration of 30 mg resulted in severe haemolysis and acute anaemia, and daily administration of 15 mg resulted in moderate haemolysis and mild anaemia[36].

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Malaria Journal

ISSN: 1475-2875

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