Table 1 Parameters and variables

n _PfEMP1

300-1000

t _asexual

Time remaining in current asexual cycle

n _minor

20-100

N _i

Number of IRBCs of type i

n _MSP

4-100

X _i

Density of IRBCs of type i per μL

X _50,innate

1000/μL

Y _{capacity,f(i)}

Non-dimensional capacity to mount antibody response to variant f(i)

τ _innate

0.5 days

Y _{antibody,f(i)}

Non-dimensional antibody response to variant f(i)

k _fever

2 C

Y _innate

Non-dimensional level of inflammatory cytokines

X _50,antibody

10/μL

Y _fever

Fever in degrees C

τ _capacity

10 days

Y _MSP,j

Adaptive immune response to MSP variant j

k _antibodymin

0.01

N _i+j,i

Number of IRBCs of type i with progeny expressing type i + j

k _minormod

0.5

Z _MS

Success probability of merozoite invasion

C _innate

0.2

N _{gametocytes,i}

Number of gametocytes of stage i

C _antibody

1.5

X _{gametocytes,mature}

Mature female gametocytes per μL

c _minormod

0.3

P _kill,i

Probability of clearing IRBC of type i

τ _abdecay

20 days

P _infect

Probability of successfully infecting mosquito

Y _memory

Varies up to 0.3

K _MSP

0.02

K _antigen

5e-9

n _{antigenswitch}

7

k _gametocyte

0.1

C _merozoite

0.5

N _{IRBCmerozoites}

16

T _asexual

2 days

Z _success

0.01

Y _gam,50

0.05