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Table 3 Potential sustainability of parasite control strategies in malaria control, elimination and eradication programmes[6467]

From: Sustainable malaria control: transdisciplinary approaches for translational applications

Subgroup Advantages Disadvantages Sustainability
Chemoprophylaxis: asexual stages Fast acting, prevents onset of infection and disease Resistance developed No, not if only targeting prevention of infection
Chemoprophylaxis: transmission blocking Sporozoite stages and hepatocytic stages targeted, could have simultaneous prevention of onset of disease Drug delivery and technical constraints Yes
Chemotherapy: treatment of disease Decrease parasite burden, treat malaria-associated symptoms Resistance developed, new drugs and targets needed Maybe, if drugs block erythrocytic development as well as formation of gametocytes
Chemotherapy: antihypnozoite Treatment of P. vivax liver stage malaria Technical constraints in drug development Maybe, species specific eliminations
Chemotherapy: transmission blocking Block human-mosquito transmission (gametocytocidal), could have simultaneous prevention of onset of disease Technical constraints in drug development Yes