Table 3 Potential sustainability of parasite control strategies in malaria control, elimination and eradication programmes[64–67]
From: Sustainable malaria control: transdisciplinary approaches for translational applications
Subgroup | Advantages | Disadvantages | Sustainability |
|---|---|---|---|
Chemoprophylaxis: asexual stages | Fast acting, prevents onset of infection and disease | Resistance developed | No, not if only targeting prevention of infection |
Chemoprophylaxis: transmission blocking | Sporozoite stages and hepatocytic stages targeted, could have simultaneous prevention of onset of disease | Drug delivery and technical constraints | Yes |
Chemotherapy: treatment of disease | Decrease parasite burden, treat malaria-associated symptoms | Resistance developed, new drugs and targets needed | Maybe, if drugs block erythrocytic development as well as formation of gametocytes |
Chemotherapy: antihypnozoite | Treatment of P. vivax liver stage malaria | Technical constraints in drug development | Maybe, species specific eliminations |
Chemotherapy: transmission blocking | Block human-mosquito transmission (gametocytocidal), could have simultaneous prevention of onset of disease | Technical constraints in drug development | Yes |