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Figure 5 | Malaria Journal

Figure 5

From: Assessment of Anopheles salivary antigens as individual exposure biomarkers to species-specific malaria vector bites

Figure 5

The IgG response and prevalence to g-5′nuc and f-5′nuc according to the level of mosquito bites and Anopheles populations ( i.e., proportion of mosquito species). Box plots of aOD values from unexposed (n = 45) and exposed (Diama, n = 46; Dielmo, n = 38 and Ndiop, n = 50) individuals to g-5′nuc (A) and f-5′nuc (B) proteins. Antibody responses are represented by aOD: the mean OD value of wells with recombinant salivary proteins minus the mean OD value of wells with coating buffer. The box plots display the median aOD value, 25th and 75th percentile. The whiskers indicate the 90th and 10th percentiles and the dots indicate the outliers. The P value was determined according to a Mann–Whitney U test (*, p <0.05; **, p <0.01; ***, p <0.001). The seroprevalence to g-5′nuc (C) and f-5′nuc (D) proteins in the four sites. The cut-off value for seropositivity (the mean aOD ± 3 standard deviations) was defined at 0.60 for g-5′nuc and 0.85 f-5′nuc, based on the IgG reactivity of sera from individuals living in Marseille that were not previously exposed to An. gambiae and An. funestus. Individuals showing aOD values above the cut-off level for seropositivity were classified as responders. The whiskers denote the 95% CI. The P values were determined by Pearson’s Chi-squared test (*, p <0.05; **, p <0.01; ***, p <0.001).

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