Table 1 Ex vivo susceptibility of the 181 isolates of Plasmodium falciparum to pyronaridine (PND), piperaquine (PPQ), chloroquine (CQ), quinine (QN), mefloquine (MQ), monodesethylamodiaquine (MDAQ), lumefantrine (LMF), dihydroartemisinin (DHA) and artesunate (AS)
Drugs | IC50 in nM | |||||||
|---|---|---|---|---|---|---|---|---|
No | geometric mean | 95% Confidence Interval | min | Q25 | median | Q75 | max | |
PND | 176 | 19.9 | 18.0-22.0 | 0.55 | 15.0 | 19.4 | 32.1 | 80.0 |
PPQ | 179 | 66.8 | 61.8-72.3 | 11.8 | 48.0 | 76.7 | 90.5 | 217.3 |
CQ | 181 | 79.8 | 66.6-95.6 | 5.0 | 22.9 | 96.0 | 246.0 | 1918.0 |
QN | 181 | 254.6 | 234.7-276.1 | 54.8 | 182.0 | 265.0 | 358.0 | 1131.0 |
MQ | 181 | 15.5 | 13.6-17.6 | 3.0 | 8.9 | 15.8 | 29.7 | 166.0 |
MDAQ | 181 | 22.1 | 19.1-25.6 | 1.5 | 11.8 | 22.6 | 43.3 | 240.0 |
LMF | 181 | 7.3 | 6.1-8.8 | 0.25 | 5.5 | 8.0 | 17.7 | 114.0 |
DHA | 181 | 1.3 | 1.2-1.5 | 0.10 | 0.9 | 1.4 | 2.4 | 21.2 |
AS | 179 | 1.1 | 1.0-1.3 | 0.10 | 0.7 | 1.3 | 2.1 | 20.6 |