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Figure 2 | Malaria Journal

Figure 2

From: Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice

Figure 2

Schematic representation of BLP-PbCSP constructs and experimental set-up. (A) Schematic representation of the mature native PbCSP (without GPI anchor) with the B-cell epitopes, the CD8+ and CD4+ T-cell sequences. Formulations used in this study including a CSP-Tlong-His and various BLP-CSP are schematically represented. (B) In several experiments, mice (n = 15/group) were immunized by subcutaneous administration of a prime and two boost injections. Blood samples were collected at day 9, 30 and 51 for serology. Two or three weeks after the second boost, mice were either sacrificed (n = 5/group) or challenged (n = 10/group). Protection was assessed by Giemsa-staining of bloodsmears from day 4 to 14 after challenge.

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