Figure 3
From: Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii
Treatment of P. yoelii infected mice with geldanamycin (17-AAG and 17-PEG-Alkyn-GA) resulted in change in invasion specificity of the parasite from normocytes to reticulocytes. Naïve mice were infected with P. yoelii and geimsa stained smears were examined everyday from each mice. After the mice became clinically sick, 17-AAG, 17-PEG-Alkyn-GA and chloroquine were injected (6th & 12fth days post infection) to three different groups (four animals in each group) of mice. Control group mice were not treated with any drug and only a single dose of chloroquine was injected. Representative blood smears are shown. Preferential invasion of reticulocytes was observed in 17-AAG and 17-PEG-Alkyn-GA treated groups of mice. iN, infected normocytes and iR, infected reticulocytes.