Table 4 Prevalence of mutations in pfcrt, pfmdr1, pfdhfr and pfdhps in pre-treatment and post-treatment samples
Position (N) | Mutants (n) | Percentage | P-value |
|---|---|---|---|
Pfcrt 76 | |||
Pre-treatment (90) | 10 | 11.1 | |
Post-treatment (12) | 4 | 33.3 | 0.22 |
Pfmdr1 86 | |||
Pre-treatment (95) | 6 | 6.3 | |
Post-treatment (19) | 8 | 42.1 | 0.0000 |
Pfdhfr 108 | |||
Pre-treatment (97) | 92 | 94.8 | |
Post-treatment (29) | 21 | 74.2 | 0.0009 |
Pfdhfr 51 | |||
Pre-treatment (97) | 73 | 75.3 | |
Post-treatment (29) | 20 | 69.0 | 0.025 |
Pfdhfr 59 | |||
Pre-treatment (97) | 80 | 82.5 | |
Post-treatment (29) | 15 | 51.7 | 0.0000 |
Pfdhps 437 (N) | |||
Pre-treatment (96) | 71 | 74 | |
Post-treatment (21) | 7 | 33.3 | 0.0003 |
Pfdhps 540 | |||
Pre-treatment (95) | 66 | 69.5 | |
Post-treatment (21) | 8 | 38.1 | 0.0000 |