Table 1 Comparative pharmacokinetic parameters of mefloquine in plasma and saliva of healthy adult volunteers after a single oral dose of mefloquine
Parameters | Plasma n = 4 | Saliva n = 4 | p value |
|---|---|---|---|
Tmax (h) | 10.0 ± 1.4 | 10.0 ± 1.1 | 1.000 |
Range | 6.0-12.0 | 8.0-12.0 | Â |
Cmax (ng/ml) | 1016.8 ± 151.04 | 571.5 ± 77.0 | 0.066 |
Range | 675.8-1367.2 | 437.5-705.4 | Â |
t 1/2 (h) | 274.3 ± 40.4.4 | 248.8 ± 39.4 | 0.678 |
Range | 175.2-353.1 | 202.3-327.2 | Â |
AUC (ng/ml.h) | 204191.6 ± 11629.6 | 104253.0 ± 7848.1 | 0.001 |
Range | 185448.9-237144.0 | 95562.3-119918.0 | Â |
CL (ml/h/kg) | 87.2 ± 16.8 | 171.7 ± 7.3 | 0.010 |
Range | 53.7-133.9 | 157.1-181.3 | Â |