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Table 1 Comparative pharmacokinetic parameters of mefloquine in plasma and saliva of healthy adult volunteers after a single oral dose of mefloquine

From: A high performance liquid chromatographic assay of Mefloquine in saliva after a single oral dose in healthy adult Africans

Parameters Plasma n = 4 Saliva n = 4 p value
Tmax (h) 10.0 ± 1.4 10.0 ± 1.1 1.000
Range 6.0-12.0 8.0-12.0  
Cmax (ng/ml) 1016.8 ± 151.04 571.5 ± 77.0 0.066
Range 675.8-1367.2 437.5-705.4  
t 1/2 (h) 274.3 ± 40.4.4 248.8 ± 39.4 0.678
Range 175.2-353.1 202.3-327.2  
AUC (ng/ml.h) 204191.6 ± 11629.6 104253.0 ± 7848.1 0.001
Range 185448.9-237144.0 95562.3-119918.0  
CL (ml/h/kg) 87.2 ± 16.8 171.7 ± 7.3 0.010
Range 53.7-133.9 157.1-181.3