Compound | IC50a (nmol/L) | R/S ratio | ||
---|---|---|---|---|
W2 | 3D7 | W2 | 3D7 | |
Chloroquine | 572 ± 112 | 25.7 ± 7.81 | - | - |
Mefloquine | 26.5 ± 2.44 | 52.2 ± 4.18 | - | - |
(R)-1 | NDb | 27.8 ± 1.42 | ND | 2.19 |
(S)-1 | ND | 12.7 ± 0.67 | ||
(R)-2 | 38.2 ± 3.63 | 74.7 ± 4.71 | 6.47 | 8.97 |
(S)-2 | 6.98 ± 0.62 | 8.33 ± 0.44 | ||
(R)-3 | 142 ± 11.2 | 205 ± 16.2 | 15.1 | 14.1 |
(S)-3 | 9.40 ± 0.91 | 14.5 ± 1.23 | ||
(R)-4 | ND | 254 ± 26.9 | ND | 7.70 |
(S)-4 | ND | 33.0 ± 1.55 | ||
(R)-5 | ND | 290 ± 43.8 | ND | 9.32 |
(S)-5 | ND | 31.1 ± 0.93 | ||
(R)-6 | 41.1 ± 9.62 | 104.5 ± 9.72 | 2.15 | 2.98 |
(S)-6 | 19.1 ± 4.03 | 35.1 ± 3.55 |