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Table 2 In vitro antimalarial activity of 4-animoalcohol quinoline enantiomers

From: Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action

Compound

IC50a (nmol/L)

R/S ratio

W2

3D7

W2

3D7

Chloroquine

572 ± 112

25.7 ± 7.81

-

-

Mefloquine

26.5 ± 2.44

52.2 ± 4.18

-

-

(R)-1

NDb

27.8 ± 1.42

ND

2.19

(S)-1

ND

12.7 ± 0.67

  

(R)-2

38.2 ± 3.63

74.7 ± 4.71

6.47

8.97

(S)-2

6.98 ± 0.62

8.33 ± 0.44

  

(R)-3

142 ± 11.2

205 ± 16.2

15.1

14.1

(S)-3

9.40 ± 0.91

14.5 ± 1.23

  

(R)-4

ND

254 ± 26.9

ND

7.70

(S)-4

ND

33.0 ± 1.55

  

(R)-5

ND

290 ± 43.8

ND

9.32

(S)-5

ND

31.1 ± 0.93

  

(R)-6

41.1 ± 9.62

104.5 ± 9.72

2.15

2.98

(S)-6

19.1 ± 4.03

35.1 ± 3.55

  
  1. a: Results expressed as mean ± standard deviation
  2. b: Not Determined