Table 3 Summary of genetic data of the Plasmodium vivax vaccine antigens analysed including Sal I sequence.
Antigen | Expression | Domain | Sites | N | H | π (s.d.) | Hd (s.d.) | dN-dS (s.d.) | Ztest (dN ≠dS) |
|---|---|---|---|---|---|---|---|---|---|
Dbp | Merozoite | Region II | 510 | 707 | 150 | 0.01103 (0.00025) | 0.9319 (0.0053) | 0.009 (0.003) | P < 0.05 |
Msp-1 | Merozoite | MSP114 and MSP120 | 512 | 400* | 28 | 0.00129 (0.00014) | 0.358 (0.031) | 0.001 (0.001) | n.s. |
Ama-1 | Merozoite | Domain I | 345 | 872 | 168 | 0.01653 (0.00016) | 0.9691 (0.0017) | 0.012 (0.004) | P < 0.05 |
Trap | Sporozoite | Regions | 837 | 168 | 38 | 0.0059 (0.00029) | 0.854 (0.018) | 0.007 (0.002) | P < 0.05 |