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Table 1 In vitro sensitivity to QN and distribution of pfmdr1 polymorphisms of the 85 adapted parasites from Thai-Myanmar and Thai-Cambodia areas

From: Polymorphisms of the pfmdr1 but not the pfnhe-1 gene is associated with in vitro quinine sensitivity in Thai isolates of Plasmodium falciparum

Area

No.

Mean QN

Mean

pfmdr 1 mutations

  

IC 50 (nM)

pfmdr 1 copy number

86Y

184F

1034C

1042D

1246Y

Thai- Myanmar

37

209.9 ± 117.1

2.9 ± 1.4*

6 (16.2%)

15 (40.5%)

4 (10.8%)

4 (10.8%)

-

Thai- Cambodia

48

197.2 ± 128.9

1.2 ± 0.7

9 (18.8%)

38 (79.2%)**

10 (20.8%)

13 (24.1%)

-

Total

85

202.8 ± 123.3

2.0 ± 1.3

15 (17.6%)

53 (61.4%)

14 (16.5%)

17 (20.0%)

-

  1. * Significant difference between two areas determined by Independent t test (p < 0.001)
  2. ** Significant difference between two areas determined by Chi square test (p < 0.001)