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Table 3 Comparison of in vitro QN sensitivity among Plasmodium falciparum with different pfmdr1 and pfnhe-1 genotypes

From: Polymorphisms of the pfmdr1 but not the pfnhe-1 gene is associated with in vitro quinine sensitivity in Thai isolates of Plasmodium falciparum

Parasite genotypes

 

No. (%)

Mean QN IC50

p value

   

(nM)

 

pfmdr1

    

86

N86

70 (82.4)

216.5 ± 127.5

0.025*

 

86Y

15 (17.6)

138.3 ± 76.1

 

184

Y184

32 (37.7)

160.4 ± 93.6

0.013*

 

184F

53 (62.3)

228.3 ± 132.6

 

1034

S1034

71 (83.5)

194.1 ± 114.0

0.144

 

1034C

14 (16.5)

246.9 ± 160.5

 

1042

N1042

68 (80)

185.8 ± 113.8

0.010*

 

1042D

17 (20)

270.5 ± 139.9

 

Copy no.

<3

69 (81.2)

195.8 ± 132.2

0.284

 

≥ 3

16 (18.8)

232.7 ± 68.8

 

pfnhe-1

DNNND repeats

0

1 (1.2)

183.6

0.958

 

1

3 (3.7)

246.1 ± 147.1

 
 

2

5 (6.2)

163.7 ± 44.2

 
 

3

26 (32.1)

203.0 ± 155.3

 
 

4

39 (48.2)

213.0 ± 108.6

 
 

5

7 (8.6)

195.9 ± 92.0

 

DDNNNDNHNDD repeats

0

3 (3.7)

115.7 ± 71.3

0.049**

 

1

14 (17.3)

272.6 ± 193.1

 
 

2

64 (79.0)

195.8 ± 102.4

 

NHNDNHNNDDD repeats

0

9 (11.1)

196.4 ± 137.6

0.378

 

1

70 (86.4)

210.8 ± 124.2

 
 

2

2 (2.5)

87.0 ± 47.4

 
  1. * Significant difference determined by Independent t test
  2. * Significant difference determined by One-way ANOVA