Parasite genotypes | Â | No. (%) | Mean QN IC50 | p value |
---|---|---|---|---|
 |  |  | (nM) |  |
pfmdr1 | Â | Â | Â | Â |
86 | N86 | 70 (82.4) | 216.5 ± 127.5 | 0.025* |
 | 86Y | 15 (17.6) | 138.3 ± 76.1 |  |
184 | Y184 | 32 (37.7) | 160.4 ± 93.6 | 0.013* |
 | 184F | 53 (62.3) | 228.3 ± 132.6 |  |
1034 | S1034 | 71 (83.5) | 194.1 ± 114.0 | 0.144 |
 | 1034C | 14 (16.5) | 246.9 ± 160.5 |  |
1042 | N1042 | 68 (80) | 185.8 ± 113.8 | 0.010* |
 | 1042D | 17 (20) | 270.5 ± 139.9 |  |
Copy no. | <3 | 69 (81.2) | 195.8 ± 132.2 | 0.284 |
 | ≥ 3 | 16 (18.8) | 232.7 ± 68.8 |  |
pfnhe-1 | ||||
DNNND repeats | 0 | 1 (1.2) | 183.6 | 0.958 |
 | 1 | 3 (3.7) | 246.1 ± 147.1 |  |
 | 2 | 5 (6.2) | 163.7 ± 44.2 |  |
 | 3 | 26 (32.1) | 203.0 ± 155.3 |  |
 | 4 | 39 (48.2) | 213.0 ± 108.6 |  |
 | 5 | 7 (8.6) | 195.9 ± 92.0 |  |
DDNNNDNHNDD repeats | 0 | 3 (3.7) | 115.7 ± 71.3 | 0.049** |
 | 1 | 14 (17.3) | 272.6 ± 193.1 |  |
 | 2 | 64 (79.0) | 195.8 ± 102.4 |  |
NHNDNHNNDDD repeats | 0 | 9 (11.1) | 196.4 ± 137.6 | 0.378 |
 | 1 | 70 (86.4) | 210.8 ± 124.2 |  |
 | 2 | 2 (2.5) | 87.0 ± 47.4 |  |