Table 4 Comparison of in vitro QN sensitivity among Plasmodium falciparum with different pfmdr1 haplotypes
Group | Pfmdr1 haplotypes | No. (%) | Mean QN IC50 (nM) ± SD | p value | |||
|---|---|---|---|---|---|---|---|
| Â | N86Y | Y184F | N1042D | Copy No. | Â | Â | Â |
1 | Y | Y/F | N | <3/≥3 | 15 (17.6) | 138.3 ± 76.1 | 0.019 |
2 | N | F | D | <3/≥3 | 17 (20.0) | 270.5 ± 139.9 |  |
3 | N | F | N | < 3 | 30 (35.3) | 200.4 ± 133.3 |  |
4 | N | Y | N | < 3 | 12 (14.1) | 162.1 ± 113.0 |  |
5 | N | Y | N | ≥3 | 11 (12.9) | 236.7 ± 74.0 |  |
Total | 85 (100) | 202.8 ± 123.3 |  | ||||