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Table 2 Characteristics of predicted Pf HRP2 kinetics in illustrative untreated infections

From: Modelling the dynamics of Plasmodium falciparum histidine-rich protein 2 in human malaria to better understand malaria rapid diagnostic test performance

Patient

Day of first fever

Pf HRP2 threshold (ng/mL)

Fitted model

Unadjusted model

   

First day above threshold (MinCM, MaxCM)

Days above threshold (range)

First day above threshold (MinCM, MaxCM)

Days above threshold (range)

S561

2

100

2,2

32-34

4,3

9-15

  

20

2,2

39-46

2,2

19-25

  

10

2,2

44-51

2,2

24-31

S707

4

100

2,2

25-29

7,5

2-6

  

20

2,2

31-35

5,5

10-15

  

10

2,1

34-40

5,3

13-25

S811

2

100

2,2

50-56

4,4

2-7

  

20

2,2

59-64

4,2

21-31

  

10

2,2

63-68

2,2

29-47

  1. The kinetics are summarized by the day they first exceed a nominated threshold under the minimum (MinCM) and maximum circulating Pf HRP2 models (MaxCM) and the total number of days they are above this threshold. A range for the number of days above the threshold is given by combining the results from the MinCM and MaxCM models. Results are presented using the mean Pf HRP2 production fitted in this study (fitted model) and also the previously reported Pf HRP2 production of 5.2 fg/parasite/replication cycle (unadjusted model) [8].
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Malaria Journal

ISSN: 1475-2875

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