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Table 5 Sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) of microscopy and RDTs versus PCR (reference method) in high- and low-transmission areas in Madagascar, 2008-2010

From: Management of uncomplicated malaria in febrile under five-year-old children by community health workers in Madagascar: reliability of malaria rapid diagnostic tests

Global Methods
Microscopy RDT
Sensitivity (95% CI) 72.7 (67.0-77.9) 61.8 (54.0-69.1
Specificity (95% CI) 100.0 (98.5-100.0 95.0 (75.1-99.9)
PPV (95% CI) 100.0 (98.1-100.0) 99.0 (94.9-100.0)
NPV (95% CI) 77.7 (72.8-82.1) 99.0 (94.9-100.0)
High transmission Methods
  Microscopy RDT
Sensitivity (95% CI) 70.1 (63.8-75.9) 60.0 (51.7-67.9)
Specificity (95% CI) 100.0 (97.9-100.0) 100.0 (81.5-100.0
PPV (95% CI) 100.0 (97.8-100.0) 100.0 (96.0-100)
NPV (95% CI) 71.9 (65.9-77.4) 23.1 (14.3-34.0
-Low transmission Methods
  Microscopy RDT
Sensitivity (95% CI) 89.2 (74.6-97.0) 75.0 (50.9-91.3)
Specificity (95% CI) 100.0 (95.4-100.0 50.0 (1.3-98.7)
PPV (95% CI) 100.0 (89.4-100.0) 93.7 (69.8-99.8)
NPV (95% CI) 100.0 (89.4-100.0) 16.7 (0.4-64.1)