Inhibition kinetics of Plasmodium Lactate Dehydrogenase with herbal extracts suggest possible enzyme inhibitor molecular interaction

Table 1

		NADH (Cofactor)		Pyruvate (Substrate)
Plant Extracts	Enzymes	Type of Inhibition	Inhibition constant K_i (µg/ml)	Type of Inhibition	Inhibition constant K_i (µg/ml)
P. amarus aqueous extract	PfLDH	Competitive	4.1±0.7	Noncompetitive	9.6±1.8
	PvLDH	Competitive	1.9±0.2	Competitive	3.5±0.2
M. koenigii chloroform extract	PfLDH	Noncompetitive	2.6±0.7	Competitive	1.1±0.3
	PvLDH	Noncompetitive	2.3±0.4	Linear Mixed	0.8±0.2

ISSN: 1475-2875