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Table 3 Prevalences of the combined pfmdr1 and pfcrt haplotypes in Fukayosi village, Bagamoyo district, Tanzania, from 2006-2011

From: Temporal trends of molecular markers associated with artemether-lumefantrine tolerance/resistance in Bagamoyo district, Tanzania

Haplotype

2006

2007

2008

2010

2011

Yearly OR

95% CI

p-value logistic regression

p-value non-parametric trend test

NFD + K

12% (5/42)

20% (46/234)

21% (40/188)

37% (13/35)

36% (43/120)

1.27

1.12-1.45

0.000

0.000

NYD + K

7% (3/42)

23% (53/234)

36% (68/188)

29% (10/35)

28% (34/120)

1.10

0.97-1.25

0.127

0.093

YYD + K

29% (12/42)

27% (64/234)

14% (27/188)

9% (3/35)

20% (24/120)

0.86

0.74-1.00

0.041

0.022

YYY + K

10% (4/42)

7% (16/234)

4% (7/188)

0% (0/35)

4% (5/120)

0.79

0.59-1.06

0.110

0.079

NFD + T

0% (0/42)

5% (12/234)

5% (10/188)

9% (3/35)

3% (3/120)

0.96

0.76-1.21

0.732

0.746

NYD + T

7% (3/42)

5% (12/234)

8% (15/188)

6% (2/35)

8% (9/120)

1.05

0.87-1.26

0.624

0.640

YYD + T

17% (7/42)

7% (17/234)

7% (14/188)

6% (2/35)

0% (0/120)

0.59

0.41-0.83

0.003

0.000

YYY + T

19% (8/42)

6% (14/234)

4% (7/188)

6% (2/35)

2% (2/120)

0.63

0.39-1.00

0.050

0.003

  1. The haplotypes refers to amino acid positions pfmdr1 N86Y, Y184F, D1246Y and pfcrt K76T. Yearly OR is the Odds Ratio for logistic regression 2006 until 2011 with year included as a continuous covariate. The OR can thus be interpreted as the relative change per year. N = asparagine, Y = tyrosine, F = phenylalanine, D = aspartic acid, K = lysine, T = threonine.