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Table 3 Prevalences of the combined pfmdr1 and pfcrt haplotypes in Fukayosi village, Bagamoyo district, Tanzania, from 2006-2011

From: Temporal trends of molecular markers associated with artemether-lumefantrine tolerance/resistance in Bagamoyo district, Tanzania

Haplotype 2006 2007 2008 2010 2011 Yearly OR 95% CI p-value logistic regression p-value non-parametric trend test
NFD + K 12% (5/42) 20% (46/234) 21% (40/188) 37% (13/35) 36% (43/120) 1.27 1.12-1.45 0.000 0.000
NYD + K 7% (3/42) 23% (53/234) 36% (68/188) 29% (10/35) 28% (34/120) 1.10 0.97-1.25 0.127 0.093
YYD + K 29% (12/42) 27% (64/234) 14% (27/188) 9% (3/35) 20% (24/120) 0.86 0.74-1.00 0.041 0.022
YYY + K 10% (4/42) 7% (16/234) 4% (7/188) 0% (0/35) 4% (5/120) 0.79 0.59-1.06 0.110 0.079
NFD + T 0% (0/42) 5% (12/234) 5% (10/188) 9% (3/35) 3% (3/120) 0.96 0.76-1.21 0.732 0.746
NYD + T 7% (3/42) 5% (12/234) 8% (15/188) 6% (2/35) 8% (9/120) 1.05 0.87-1.26 0.624 0.640
YYD + T 17% (7/42) 7% (17/234) 7% (14/188) 6% (2/35) 0% (0/120) 0.59 0.41-0.83 0.003 0.000
YYY + T 19% (8/42) 6% (14/234) 4% (7/188) 6% (2/35) 2% (2/120) 0.63 0.39-1.00 0.050 0.003
  1. The haplotypes refers to amino acid positions pfmdr1 N86Y, Y184F, D1246Y and pfcrt K76T. Yearly OR is the Odds Ratio for logistic regression 2006 until 2011 with year included as a continuous covariate. The OR can thus be interpreted as the relative change per year. N = asparagine, Y = tyrosine, F = phenylalanine, D = aspartic acid, K = lysine, T = threonine.