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Table 1 Ex vivo susceptibility of 34 Plasmodium falciparum isolates from Dakar to chloroquine (CQ), monodesethylamodiaquine (MDAQ), lumefantrine (LMF), dihydroartemisinin (DHA), quinine (QN), mefloquine (MQ) and doxycycline (DOX)

From: Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal, in 2010: an ex vivo and drug resistance molecular markers study

Drug

No

Isolate IC50

Resistance or reduced susceptibility

  

Mean

CI95%

Min

Max

Cut-off

%

CQ

34

41.3 nM

26.7-64.0

5.1

1958

77 nM

24.2

MDAQ

34

19.4 nM

13.3-28.4

1.6

179

61 nM

11.8

LMF

34

9.8 nM

6.3-15.2

0.77

139

115 nM

2.9

DHA

32

3.6 nM

2.8-4.6

1.2

11.0

12 nM

0

QN

34

141.3 nM

93.7-213.0

5.2

1195

611 nM

9.7

MQ

32

30.1 nM

22.2-41.0

5.3

86.9

30 nM

62.1

DOX

32

9.2 μM

6.5-12.9

0.5

41.9

37 μM

10.3

  1. Mean: geometric mean.
  2. CI95%: 95% confidence interval.