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Output
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Level of G6PD deficiency
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In the absence of a consensus a quantitative read out may be most appropriate. In the absence of a consensus a qualitative read out may be controversial.
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Use case
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On patients with confirmed malaria infection.
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This is an additional cost to malaria case management.
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User
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Someone who performs malaria RDTs or microscopy.
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A quantitative read-out could come from a reader or scanner.
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Sensitivity and Specificity
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Must accurately classify all patients with G6PD levels below a pre-defined cut-off. No patients with potentially dangerously low G6PD levels should be misclassified as normal.
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It is unclear on what the suitable cut-off should be. Too low and the risk of haemolysis increases. Too high primaquine is denied to more patients who need it.
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Environmental tolerance
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25-38°C, 40-90% humidity
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Enzyme activity is extremely temperature sensitive.
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Result read window
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< 20 minutes
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Technically challenging for an enzyme reaction.
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Specimen type
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Finger stick
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Currently very limited data with finger stick specimens.
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