Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys

Table 1 Effect of the combination of tetrandrine and chloroquine against infected chloroquine-resistant Plasmodium falciparum malaria in Aotus monkeys

Expt. no.	Monkey no.	Dose^a (Mg/kg)	Parasites cleared	Days from initial dose to parasite clearance	Days from final dose to recrudescence	Re-treating-post recrudescence (mg/kg)	Cured
1	025	15(tt)	+			30 (tt) ^d	(++)
		20(cq)		16	23	20 (cq)
	055	15(tt)	+			30(tt) ^d	(++)
		20(cq)		8	33	20(cq)
	016	15(tt)	+			30 (tt) ^d	(++)
		20(cq)		8	13	20 (cq)
2	705	30(tt)	+			60 (tt) ^d	(++)
		20(cq)		7	9	20 (cq)
	706	60(tt)	+			120 (tt) ^d	(++)
		20(cq)		7	14	20 (cq)
	698^b	-	-
CQ^c	520	20(cq)	-
	432	20(cq)	-
	349	20(cq)	-
	544	20(cq)	-
	631	20(cq)	-

a tt and cq represent tetrandrine and chloroquine respectively.
b This monkey as a non-treated control died within 2 weeks after inoculation with the parasite.
c Monkeys were treated with CQ alone.
d Monkeys were cured after two week combinational cq and tt treatment=(++).

ISSN: 1475-2875