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Figure 1 | Malaria Journal

Figure 1

From: Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

Figure 1

The AS lineage of drug resistant parasites, featuring artemisinin (ART) phenotypes and ubp-1 genotypes. Parasites were selected by passage in presence of drugs shown [29–33]. Artemisinin resistance (phenotype 1) appears during selection by chloroquine [25, 26] and is mediated by either of two mutations in the ubp-1 gene (PCHAS_020720) [25, 27]. AS-ART was generated during selection by artemisinin [29]. Its increased resistance to artemisinin (phenotype 2) and its genotype is the subject of the present study. *, parasites used in the present study; wt, wild-type; kg bw, kilograms body weight.

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Malaria Journal

ISSN: 1475-2875

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