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Table 2 Genetic polymorphisms identified in the pfap2-μ gene (PF3D7_1218300)

From: Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

Nucleotide

Reference sequence (3D7) variant

Codon, variant

Amino acid substitution

Location

300

ATA

ATC

I100syn

Rwanda

381

GTG

GTT*/GTC

V127syn

Brazil

437

AG A

AA A

R146K

Rwanda

479

AG T

AA T

S160N

Rwanda, STP

486

ATT

ATC

I162syn

Rwanda

489

GAA

GAG*

E163syn

Rwanda, STP

596

AA A

AC A

K199T

Rwanda

699

AAT

AAG

N233K

Rwanda

1311

TTC

TTA

F437L

Rwanda

Insertions

 

Codon insertion

Amino acid insertion

 

699

AAT

AATAAT

233 + N

STP

972

AAT

AATAAT

324 + N

Rwanda, STP

987

AAT

AATAAT

329 + N

STP

  1. Polymorphic bases are underlined. * - SNP previously identified and recorded in PlasmoDB. Non-synonymous SNPs are shown with amino acid substitutions (bold). STP, Sao Tome and Principe.