From: Creative solutions to extraordinary challenges in clinical trials: methodology of a phase III trial of azithromycin and chloroquine fixed-dose combination in pregnant women in Africa
Observed pooled proportion for the primary endpoint at N = 1,000
Total sample size required
≤0.28
5,044
>0.28 to ≤0.32
4,206
>0.32 to ≤0.36
3,552
>0.36 to ≤0.40
3,030
>0.40
2,602