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Table 2 Univariate analysis of factors associated with early parasite response in Africa

From: Early parasitological response following artemisinin-containing regimens: a critical review of the literature

 

Day 1

Day 2

Day 3

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Age

0.97 (0.95-0.99)

0.016

1.01 (0.97-1.04)

0.767

1.04 (0.96-1.12)

0.354

Log e parasitaemia

1.74 (1.26-2.39)

0.001

1.74 (1.25-2.42)

0.001

2.68 (1.00-7.18)

0.050

Year

0.88 (0.78-1.00)

0.051

0.89 (0.78-1.02)

0.087

0.79 (0.64-0.99)

0.039

Artemisinin derivative

 

<0.001

 

0.002

 

0.141

Artemether

1.00

 

1.00

 

1.00

 

Artemisinin

0.87 (0.41-1.86)

0.718

NA

 

NA

 

Artesunate

0.83 (0.72-0.95)

0.009

1.06 (0.84-1.34)

0.617

1.16 (0.56-2.41)

0.692

DHA

0.65 (0.51-0.83)

<0.001

0.57 (0.40-0.80)

0.001

0.21 (0.02-1.79)

0.154

Treatment

 

0.002

 

0.004

 

0.494

DHA+PIP

1.00

 

1.00

 

1.00

 

AL

1.50 (1.19-1.88)

0.001

1.70 (1.21-2.40)

0.002

4.70 (0.55-40.03)

0.157

AS+MQ

1.34 (0.86-2.08)

0.19

2.25 (0.98-5.14)

0.055

6.03 (0.43-84.46)

0.182

AS+SP

1.08 (0.48-2.43)

0.851

2.17 (1.33-3.54)

0.002

7.60 (0.86-66.87)

0.067

AS+AQ

1.30 (0.98-1.73)

0.073

2.05 (1.39-3.03)

<0.001

5.99 (0.74-48.64)

0.094

AS alone

0.73 (0.16-3.29)

0.685

0.76 (0.29-2.01)

0.583

ND1

 
  1. Only patients who received artemisinin derivative until Day 1 (2 or 3) are included for analysis of Day 1 (2 or 3). Study arms with rectal artesunate were excluded. Positivity rate equal to 0% on Day 2 was carried forward to Day 3 if Day 3 rate was not reported.
  2. ND= There were no patients available with detectable parasitaemia in this category so the OR could not be estimated. P-value = 1.000 for comparison with DHA+PIP treatment (Fisher’s exact test). For the purpose of logistic model this treatment group was merged with all other treatments (not included in the listed categories).
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Malaria Journal

ISSN: 1475-2875

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