Regions of disease elimination and persistence after PEV and ITN distribution. Left panel: The separatrix between the regions of parameter space with disease persistence (dark blue) and local disease elimination (white). Individual simulations are marked either with a cross (for successful elimination) or a circle (disease persistence). ITNs and 50%-efficacy pre-erythrocytic vaccines (PEV) are distributed independently at 80% coverage. Right panel: The location of the separatrix (50% probability isocline) between regions of parameter space with disease persistence for PEV efficacy values ranging from 0% to 90%.