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Figure 4 | Malaria Journal

Figure 4

From: Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine

Figure 4

Pf CSP-SAPN-induced antibody is able to deter sporozoite liver stage development in a concentration dependent manner. Human hepatocytes cultured in the presence of P. falciparum sporozoites and serum from either Pf CSP-SAPN-immunized mice (at 1:20, 1:200, or 1:1,000 dilution), Pv CSP-SAPN immunized mice (1:20 dilution) or PBS-sham immunized mice (1:20 dilution). Shown are the reductions in the percent of infected hepatocytes following four days in culture compared to the PBS (1:20 dilution) incubated controls. Error bars are the SD of the mean; Pf CSP-SAPN and Pv CSP-SAPN at 1:20 dilution show significance using Student’s t-test.

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Malaria Journal

ISSN: 1475-2875

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