Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal

Table 3 Prevalence of resistance mutations in 2009 among those typed and estimated prevalence in the population

	Study samples		Prevalence in population^$
	Control area	SMC area	Control area (%)	SMC area (%)	Prevalence ratio^	p-value
					SMC/ non SMC (95% CI)
Prevalence of parasitaemia among children surveyed	41/3320	9/3326	1.33	0.22	0.16 (0.06, 0.42)	<0.001
Prevalence of mutations among typed
dhfr triple (51, 59, 108)	27/34	4/6	0.98	0.18	0.18 (0.059, 0.58)	0.004
dhps-437	25/35	4/6	0.88	0.18	0.21 (0.064, 0.66)	0.008
SP resistant mutant (dhfr triple + dhps 437)	23/34	4/6	0.84	0.18	0.22 (0.068, 0.69)	0.01
crt CVIET mutation	13/35	3/6	0.46	0.14	0.30 (0.10, 0.86)	0.026
mdr 86Y	15/33	4/6	0.56	0.18	0.32 (0.11, 0.92)	0.034
mdr 184F	28/34	5/6	1.02	0.23	0.22 (0.086, 0.58)	0.002
AQ resistant mutant (mdr 86Y + crt CVIET)	9/33	2/6	0.34	0.09	0.27 (0.078, 0.92)	0.036
SP resistant & AQ resistant	8/32	2/6	0.31	0.09	0.29 (0.08, 1.07)	0.064

^ Prevalence ratios accounting for survey design. $For genotypes, prevalence among population is estimated as the product of 1) the probability of a resistant genotype among the typed samples and 2) the probability positive among samples with a definitive result (positive or negative) for asexual stage parasitaemia. Standard errors estimated by the delta method as described in the methods section.

ISSN: 1475-2875