Table 5 Prevalence of resistance mutations among children with parasitaemia pooled over the entire study
Mutation | Non-SMC area n positive / N typed (%) | SMC area n positive / N typed (%) | Crude prevalence ratio SMC/ non SMC (95% CI) | Adjusted prevalence ratio* SMC/ non SMC (95% CI) | p-value |
|---|---|---|---|---|---|
dhfr triple (51, 59, 108) | 59/76 (77.6) | 29/34 (85.3) | 1.10 (0.91, 1.32) | 0.90 (0.79, 1.02) | 0.087 |
dhps-437 | 55/77 (71.4) | 28/34 (82.4) | 1.15 (0.93, 1.42) | 0.98 (0.80, 1.21) | 0.867 |
SP resistant mutant (dhfr triple + dhps 437) | 51/76 (67.1) | 27/34 (79.4) | 1.18 (0.94, 1.49) | 0.89 (0.75, 1.06) | 0.182 |
crt CVIET mutation | 23/76 (30.3) | 12/30 (40.0) | 1.32 (0.76, 2.31) | 1.46 (0.70, 3.05) | 0.311 |
mdr 86Y | 15/58 (25.9) | 16/32 (50.0) | 1.93 (1.1, 3.38) | 1.86 (1.04, 3.34) | 0.037 |
mdr 184F | 44/59 (74.6) | 23/32 (71.9) | 0.96 (0.74, 1.26) | 1.09 (0.82, 1.47) | 0.550 |
AQ resistant mutant (mdr 86Y + crt CVIET) | 9/52 (17.3) | 7/29 (24.1) | 1.39 (0.58, 3.37) | 1.90 (0.71, 5.09) | 0.205 |
SP-AQ resistant | 8/48 (16.7) | 7/28 (25.0) | 1.50 (0.61, 3.72) | 2.04 (0.73, 5.67) | 0.173 |