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Figure 1 | Malaria Journal

Figure 1

From: Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria

Figure 1

Continuous delivery of low doses of nimodipine together with artesunate improves survival of ECM mice. Cumulative survival (A), rectal temperature (B), and course of parasitaemia (C, left) of late-stage ECM mice treated with artesunate (32 mg/kg) together with slow continuous delivery via osmotic pumps of vehicle (n=73) and nimodipine at 0.5 mg/kg/day (n=42) or 2.5 mg/kg/day (n=28). Relative decay of viable circulating parasites 24 h after first dose of artesunate in relation to normalized parasitaemia before treatment was calculated to compare the efficacy of parasite clearance in each group (C, right). In panel A, p<0.05 when nimodipine-treated groups were compared with control mice treated with vehicle. **p<0.01. Results were pooled from three independent experiments.

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