Figure 1From: Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malariaContinuous delivery of low doses of nimodipine together with artesunate improves survival of ECM mice. Cumulative survival (A), rectal temperature (B), and course of parasitaemia (C, left) of late-stage ECM mice treated with artesunate (32 mg/kg) together with slow continuous delivery via osmotic pumps of vehicle (n=73) and nimodipine at 0.5 mg/kg/day (n=42) or 2.5 mg/kg/day (n=28). Relative decay of viable circulating parasites 24 h after first dose of artesunate in relation to normalized parasitaemia before treatment was calculated to compare the efficacy of parasite clearance in each group (C, right). In panel A, p<0.05 when nimodipine-treated groups were compared with control mice treated with vehicle. **p<0.01. Results were pooled from three independent experiments.Back to article page