Skip to main content

Table 3 Prevalence of molecular markers associated with P. falciparum resistance to CQ and SP in symptomatic and asymptomatic children

From: Prevalence of the molecular marker of Plasmodium falciparum resistance to chloroquine and sulphadoxine/pyrimethamine in Benin seven years after the change of malaria treatment policy

Molecular marker

Population n (%)

Symptomatic n (%)

Asymptomatic n (%)

p-value

T76 (n = 213)

200 (93.9%)*

68/72 94.4%)

132/141 (93.6%)

1a

Y86 (n = 212)

121 (57.1%)

29/71 (40.8%)

92/141 (65.2%)

0.03b

T76Y86 (n = 212)

117 (55.2%)

28/71 (39.4%)

89/140 (63.6%)

0.03b

G437 (n = 210)

150 (71.4%)

48/73 (65.8%)

102/137 (74.5%)

0.42b

E540 (n = 210)

0%

0%

0%

 

I51 (n = 212)

204 (96.2%)

69/73 (94.5%)

135/139 (97.1%)

0.45a

R59 (n = 212)

199 (93.9%)

69/73 (94.5%)

130/139 (93.5%)

1a

N108 (n = 212)

207 (97.6%)

71/73 (97.3%)

136/139 (97.8%)

0.72a

IRN1 (n = 212)

194 (91.5%)

67/73 (91.8%)

127/139 (91.4%)

0.61b

IRNG2 (n = 210)

138 (65.7%)

44/73 (60.3%)

94/137 (68.6%)

0.15b

  1. 1pfdhfr triple mutants (I51, R59, and N108).
  2. 2pfdhfr/pfdhps quadruple mutants (pfdhfr I51, R59, N108 and pfdhps G437).
  3. *p < 0.001 of Chi 2 test (comparison between T76 and Y86, T76 and T76Y86).
  4. a p-value of fisher test.
  5. b p-value of Chi 2 test.