TY - JOUR AU - Schneider, Kristan A. AU - Escalante, Ananias A. PY - 2013 DA - 2013/01/11 TI - Fitness components and natural selection: why are there different patterns on the emergence of drug resistance in Plasmodium falciparum and Plasmodium vivax? JO - Malaria Journal SP - 15 VL - 12 IS - 1 AB - Considering the distinct biological characteristics of Plasmodium species is crucial for control and elimination efforts, in particular when facing the spread of drug resistance. Whereas the evolutionary fitness of all malarial species could be approximated by the probability of being taken by a mosquito and then infecting a new host, the actual steps in the malaria life cycle leading to a successful transmission event show differences among Plasmodium species. These “steps” are called fitness components. Differences in terms of fitness components may affect how selection imposed by interventions, e.g. drug treatments, differentially acts on each Plasmodium species. Thus, a successful malaria control or elimination programme should understand how differences in fitness components among different malaria species could affect adaptive evolution (e.g. the emergence of drug resistance). In this investigation, the interactions between some fitness components and natural selection are explored. SN - 1475-2875 UR - https://doi.org/10.1186/1475-2875-12-15 DO - 10.1186/1475-2875-12-15 ID - Schneider2013 ER -