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Table 2 % Ratio of untransformed data (Artefan® to Coartem ® ) and a comparison of data obtained by Norvatis

From: Comparison of bioavailability between the most available generic tablet formulation containing artemether and lumefantrine on the Tanzanian market and the innovator’s product

Primary Parameter Artefan ® Coartem ® P value % Ratio of test to reference Norvatis Data on file (Riamet)
Arithmetic mean ± SD Arithmetic mean ± SD    Arithmetic mean
(*) (*)    
Tmax (h) 6.11±2.698 6.2±2.2 0.8950 - 6 – 8
Cmax (ng/ml) 4206.9±2942.5 (3144.0) 4438.81±2548.432 (3742.267) 0.7836 84.0 5100-9800
AUC0-168 (ng.h/ml) 123758.9±83527.5 (93175.97) 135430.7±86814.8 (109729.0) 0.6612 84.5 -
AUC0-∞ (ng.h/ml) 138189.7±94959.8 (102441.5) 149530.2±95109.4 (121576.3) 0.7022 84.3 108000- 243000
  1. *Geometric mean.