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Table 1 Apparent kinetic constants for Plasmodium falciparum FPPS,(rPfFPPS)

From: Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum

Varied substrate

Fixed substrate

K M (μM)

V max (nmol/min/mg)

DMAPP (0–150 μM)

IPP 50 μM

68 ± 5

452.5 ± 16

GPP (0–50 μM)

IPP 50 μM

7.8 ± 1.3

341 ± 19

FPP (0–50 μM)

IPP 50 μM

2.06 ± 0.4

326.5 ± 16

IPP (0–80 μM)

DMAPP 100 μM

2 ± 0.3

169 ± 5.4

IPP (0–80 μM)

GPP 40 μM

0.81 ± 0.1

224 ± 3.4

IPP (0–50 μM)

FPP 50 μM

2.4 ± 0.3

155.6 ± 4

  1. Concentration ranges for each varied substrate are indicated. Activity versus varied substrate concentration plots are depicted on Additional file 4.
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Malaria Journal

ISSN: 1475-2875

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