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Figure 6 | Malaria Journal

Figure 6

From: A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria

Figure 6

Study flow chart and classification results from CART analysis. The initial training and testing study (on left) represents the original data from [15]. The validation study, using 40 new cases, is shown on the right with the original classifications rules applied (upper results table) and a de novo set of classifications rules (based on the 40 new cases, lower results table). The first node (separating patients with any cerebral sequestration from patients without evidence of cerebral sequestration) remained stable (23.3% vs 21%) with no classification errors. The second node (separating patients with sequestration only from patients with sequestration and extravascular pathology including ring haemorrhages) also remained stable (58.5 pg/100 vessels vs 55.5 pg/100 vessels). A third node was required (<= or >94.9 UPP/100 vessels) to separate the remainder of these latter two categories; however there were, in total, four classification errors using this new model.

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