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Table 2 In vitro anti-plasmodial activity of examined compound

From: Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica

Compound

Anti-plasmodial activity (IC50μg/ml)

Cytotoxity

Selectivity indices

A

B

IC50(μg/ml)

A

B

Conessine

1.9

1.3

14

7

10

Chloroquine

0.07

0.051

-

-

-

  1. A: schizont maturation Method; B: pLDH method; cytotoxicity IC50 (As per WHO criteria) >16 μg/ml- non cytotoxic; selectivity indices = ratio of IC50 of cytotoxic activity/IC50 of anti-plasmodial activity [8].
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Malaria Journal

ISSN: 1475-2875

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