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Table 3 PCR-RFLP* findings of polymorphism on the pfdhfr and pfdhps gene from samples (n = 31) collected in Kalabakan, Sabah

From: High prevalence of mutation in the Plasmodium falciparum dhfr and dhps genes in field isolates from Sabah, Northern Borneo

 

pfdhfr

pfdhps

Codons

ala

asn

cys

ser

ser

ile

ala

lys

ala

 

16

51

59

108

108

164

437

540

581

 

val

ile

arg

asn

thr

leu

gly

glu

gly

% Mutation

16.12

0

100

58.06

0

80.64

100

0

74.19

Wild-Type

83.87

100

0

49.94

100

19.35

0

100

25.8

  1. * PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism
  2. § Alanine = ala, Valine = val, Asparagine = asn, Isoleucine = ile, Cysteine = cys, Arginine = arg, Serine = ser, Threonine = thr, Leucine = leu, Glycine = gly, Lysine = lys, Glutamic acid = glu.