Table 5 The frequency of mutant genotypes combining mutations in the pfdhfr and pfdhps genes in isolates collected during the study in Kalabakan (n = 31)
Pfdhfr codons | Pfdhps codons | Frequency of mutant genotype | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
ala 16Â val | asn 51 ile | cys 59 arg | ser 108 asn | ser 108 thr | ile 164 leu | ala 437 gly | lys 540 glu | ala 581 gly | % of mutant genotype in sample | dhfr/dhps combination |
val | asn | arg | asn | ser | leu | gly | Lys | gly | 3.22 (1/31) | 4dhfr, 2 dhps |
val | asn | arg | ser | ser | leu | gly | Lys | gly | 3.22 (1/31) | 3dhfr, 2 dhps |
ala | asn | arg | asn | ser | leu | gly | Lys | gly | 41.94 (13/31) | 3dhfr, 2 dhps |
val | asn | arg | ser | ser | ile | gly | Lys | gly | 9.67 (3/31) | 2dhfr, 2dhps |
ala | asn | arg | ser | ser | leu | gly | Lys | gly | 16.12 (5/31) | 2dhfr, 2dhps |
ala | asn | arg | ser | ser | ile | gly | Lys | gly | 3.22 (1/31) | 1dhfr, 2dhps |
ala | asn | arg | ser | ser | ile | gly | Lys | ala | 3.22 (1/31) | 1dhfr, 1dhps |
ala | asn | arg | ser | ser | leu | gly | Lys | ala | 6.45 (2/31) | 2dhfr, 1dhps |
ala | asn | arg | asn | ser | leu | gly | Lys | ala | 12.90 (4/31) | 3dhfr, 1dhps |