Figure 1

Schematic of the cell population models. (A) parasite stages. (B) Host immunity mechanisms. (Strictly speaking, the host immunity models are not those of cell populations, but the dynamics are similar and controlled by host cell systems.) (C) Erythrocyte stages. For each population phenotype, D is the population- mean duration and σ is the standard deviation in the duration. In (A), r is the proportion of asexual merozoites which are diverted down the pathway of gametocyte development. Interactions between cell phenotypes are explained in depth in the Methods, as well as description of model parameters.