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Figure 6 | Malaria Journal

Figure 6

From: Host immune constraints on malaria transmission: insights from population biology of within-host parasites

Figure 6

Effects of gametocyte-specific antibodies in simulated P. vivax infection on gametocyte levels. Results from simulated P. vivax infections that resolved within three years from primary release of merozoites were binned by parasite-days of the intracellular asexual forms, PD Asx , and also by a measure of the ability of the antibody response to clear their target, IS Gcy . See text for definitions. The horizontal length of an individual block shows the bin size in PD Asx , and the vertical extent of a block show the bin size in IS Gcy . Results are only shown for bins that contained 10 or more simulations. (A) Fraction of simulations making mature gametocytes if a model antibody response attacks mature gametocytes. (B) Same as (A), except a model antibody response attacks immature gametocytes. Color code for panels (A) and (B) is the same as for panels (A) and (B) in Figure 5. (C) Logarithm mean of parasite days of mature gametocytes PD MG for simulated infections producing mature gametocytes if a model antibody response attacks mature gametocytes. (D) Same of (C) except a model antibody response attacks immature gametocytes. Color code for panels (C) and (D) are the same as for panels (D) and (E) in Figure 5. Note: host died in all simulate infections for which PD Asx > 105μL−1day, and parasite was cleared in all simulated infections if PD Asx < 105μL−1day.

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