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Table 3 Patients’ characteristics at inclusion

From: Population pharmacokinetics of mefloquine, piperaquine and artemether-lumefantrine in Cambodian and Tanzanian malaria patients

  Kibaoni (Tanzania)*
Characteristic AM / DHA† LF / DLF†
Total patients 135 143
Sex male / female (%) 56 (41) / 79 (59) 62 (43) / 81 (57)
Age median (range) [years] 10 (1–78) 9 (1–78)
Body weight median (range) [kg] 20 (6.5–150) 20 (6.5–150)
Height median (range) [cm] 126 (52–181) 126 (52–181)
Pregnancy (%) 3 (2) 3 (2)
Smokers (%) 1 (1) 1 (1)
Median time sick (range) [days] 3 (1–14) 3 (1–14)
Median body temperature (range) [°C] 37.5 (35.2–40.4) 37.6 (35.2–40.4)
Median asexual parasites (range) [μL-1] 15,360 (120– > 399,960)a 15,360 (120– > 399,960)a
Median respiratory rate (range) [min-1] 24 (16–38) 24 (16–38)
Median hematrocrit (range) [%] N.A. N.A.
Median haemoglobin (range) [g/dL] 10.5 (5.1–16.3) 10.4 (5.1–16.3)
  Phnom Dék (Cambodia)
Characteristic AS / DHA† and MQ
Total patients 63
Sex male / female (%) 37 (59) / 26 (41)
Age median (range) [years] 18 (2–57)
Body weight median (range) [kg] 43 (10.5–66)
Height median (range) [cm] 153 (73–172)
Pregnancy (%) N.A.
Smokers (%) 17 (27)
Median time sick (range) [days] 2 (2–3)
Median body temperature (range) [°C] 38.6 (37.9–40.4)
Median asexual parasites (range) [μL-1] 19,600 (1,200–160,000)
Median respiratory rate (range) [min-1] 28 (20–38)
Median hematrocrit (range) [%] 30 (24–37)
Median haemoglobin (range) [g/dL] N.A.
  Pramoy (Cambodia)*
Characteristic DHA PPQ
Total patients 56 60
Sex male / female (%) 34 (61) / 22 (39) 38 (63) / 22 (37)
Age median (range) [years] 18 (7–53) 18 (7–53)
Body weight median (range) [kg] 42 (15–67) 42 (15–67)
Height median (range) [cm] 151 (105–171) 152 (105–171)
Pregnancy (%) N.A. N.A.
Smokers (%) 12 (21) 14 (23)
Median time sick (range) [days] 2 (1–3) 2 (1–3)
Median body temperature (range) [°C] 38.4 (37.8–39.8) 38.4 (37.8–39.8)
Median asexual parasites (range) [μL-1] 16,858 (1038–219,333) 17,229 (1038–219,333)
Median respiratory rate (range) [min-1] 28 (20–40) 28 (20–40)
Median hematrocrit (range) [%] 41 (30–50) 41 (30–50)
Median haemoglobin (range) [g/dL] N.A. N.A.
  1. Abbreviations: AM artemether, AS artesunate, DHA dihydroartemisinin, LF lumefantrine, MQ mefloquine, PPQ piperaquine.
  2. * The number of patients included for the final analysis was not equal for the artemisinin-derivative and the partner drug.
  3. † Parent drug / metabolite.
  4. a Asexual parasites were counted against 200 white blood cells and converted to parasites/μL by assuming a density of 8,000 white blood cells/μL.