Population analysis

Bootstrap evaluation


Parameter

Estimate

S.E.^{a}

IIV^{b}

S.E.^{c}

Mean of 200

S.E.

95% C.I.^{d}


Artemether
       
CL [L/h/kg]

24.7 × BW^{0.75}

10%

44%

17%

24.4 × BW^{0.75}

10%

19–29

θ
_{
INH
}

−0.3

45%
  
−0.27

60%

0.5–1.1

V_{
C
} [L/kg]

129

20%
  
133

26%

88–232

V_{
M
} [L]

Fixed to V_{
C
}
      
k_{a} [h^{1}]

0.27

11%

119%

11%

0.27

14%

0.21–0.35

k_{23} [h^{1}]

5.86

21%

68%

9%

5.83

25%

3.6–9.7

CL_{
met
} [L/h]

419

30%
  
440

42%

213–927

σ_{
C
} (CV%)

74%

9% ^{c}
  
73%

11% ^{c}

59%–86%

σ_{
M
} (CV%)

119%

11% ^{c}
  
116%

9% ^{c}

88%–149%

Lumefantrine
       
CL [L/h/kg]

$0.84\times {\mathrm{BW}}^{{\theta}_{\mathit{BWCL}}}$

28%

38%

14%

$0.87\times {\mathrm{BW}}^{{\theta}_{\mathit{BWCL}}}$

24%

0.511.37

θ
_{
BWCL
}

0.52

19%
  
0.51

14%

0.360.65

V_{
C
} [L/kg]

$59.9\times {\mathrm{BW}}^{{\theta}_{\mathit{BWCL}}}$

28%

33%

11%

$59.5\times {\mathrm{BW}}^{{\theta}_{\mathit{BWCL}}}$

24%

35.1–91.9

θ
_{
BWVC
}

0.35

28%
  
0.34

19%

0.190.45

V_{
M
} [L]

Fixed to V_{
C
}
      
k_{
a
} [h^{1}]

0.54

31%
  
0.48

43%

0.11–0.88

F_{0} [mg]

2.53

14%

103%

14%

2.45

15%

1.58–3.28

k_{23} [h^{1}]

3.7 × 10^{4}

12%

38%

15%

3.7 × 10^{4}

9%

(3.0–4.4) × 10^{4}

CL_{
met
} [L/h]

4.8

10%
  
4.6

13%

3.4–5.7

σ_{
C
} (CV%)

60%

9% ^{c}
  
61%

31%

55%–77%

σ_{
M
} [μmolL^{1}]

0.013

4% ^{c}
  
0.013

45%

0.010–0.016

Mefloquine
       
CL [L/h/kg]

0.10 × BW^{0.75}

5%

12%

88%

0.10 × BW^{0.75}

5%

(0.09–0.11)

V_{
C
} [L/kg]

8.93 × BW

6%

19%

96%

9.01 × BW

6%

(8.04–10.20)

k_{a} [h^{1}]

0.15

14%
  
0.15

14%

0.12–0.19

F_{0} [mg]

33.1

56%

175%

48%

31.0

43%

11.8–48.1

σ_{
C
} [μmolL^{1}]

43%

6% ^{c}
  
43%

6% ^{c}

0.14–0.22

Piperaquine
       
CL [L/h/kg]

4.50 × BW^{0.75}

13%

45%

61%

4.26 × BW^{0.75}

22%

(3.24–5.76)

V_{
C
} [L/kg]

346 × BW

12%

65%

48%

347 × BW

13%

(260–432)

Q [L/h]

122

13%
  
126

13%

86–158

V_{
P
} [L]

18,600

22%

50%

77%

20,053

37%

8,778–28,422

k_{a} [h^{1}]

0.93

28%
  
1.00

34%

0.35–1.52

F_{0} [mg]

123

18%
  
125

18%

75–171

σ_{
C
} [μmolL^{1}]

41%

10% ^{c}
  
41%

6% ^{c}

0.14–0.21

 Abbreviations: CL clearance, BW body weight, θ_{
INH
} inhibitors effect (CYP3A4 and/or CYP2C19) on CL expressed as (1 θ_{
INH
} × INH), V_{
C
} central volume of distribution, Q intercompartment clearance, V_{
M
} volume of distribution of the metabolite, V_{
P
} peripheral volume of distribution, k_{
a
} firstorder absorption rate constant, F_{0} residual amount from the previous treatment, k_{23} metabolism rate constant, CL_{met} metabolite clearance, σ_{
C
} exponential residual error for the central compartment, σ_{
M
}: exponential residual error for the metabolite compartment.
 ^{a} Standard error (S.E.) of the estimate θ_{
i
} defined as S.E estimate/estimate, expressed as a percentage.
 ^{b} Interindividual variability.
 ^{c} Standard error (S.E.) of the coefficient of variation defined as √S.E estimate/estimate, expressed as a percentage.
 ^{d} 95% confidence interval (C.I.).