Hierarchical clustering of the CRR mismatch distribution parameters and its relation to vk genotype, geographic origin and carboxyl end. The mismatch distribution parameters (average p, prop. 0, prop. >0.25, skewness and σ (p) were normalized to the highest value and cluster by uncentred absolute correlation. The frequency of sequences by vk genotype and geographic origin are indicated. Samples from this study are indicated in red. Carboxyl type was indicated by the absence or presence of domain ANKKAEDA as type I and II, respectively, and the presence of ANKKAGDA domain as type III. LA, Latin America. OA, outside Latin America; 1 indicate recombinant sequences.