Molecular epidemiology of Plasmodium vivax in Latin America: polymorphism and evolutionary relationships of the circumsporozoite gene

Table 3 Statistical differences of mismatch distribution parameters for Plasmodium vivax csp CRR by vk genotype and geographic origin

Comparison:		n	Measure	*average p*	*Prop. 0*	*Prop. >0.25*	*skewness*	*σ (p)*
A:	Worldwide csp genotypes:
	VK210	53	mean	0.082	0.1366	0.0156	0.7693	0.0034
	VK210	53	SD	0.0129	0.0443	0.0194	0.5983	0.0011
	VK247	25	mean	0.0959	0.1371	0.0825	1.2256	0.007
	VK247	25	SD	0.0061	0.0227	0.0092	0.2442	0.0007
	p			*0.0001*	NS	*0.0001*	*0.0005*	*0.0001*
B:	vk210 worldwide clusters:
	LA-C1*	21	mean	0.0723	0.1699	0.0062	0.5463	0.0027
	LA-C1*	21	SD	0.0064	0.0434	0.0100	0.7431	0.0011
	OA-C2	30	mean	0.0886	0.1132	0.0223	0.9443	0.0039
	OA-C2	30	SD	0.0122	0.0300	0.0223	0.4237	0.0008
	p			*0.0001*	*0.0001*	*0.0032*	*0.0189*	*0.0001*
C:	vk210 Latin American groups:
	LA-C1A	10	mean	0.0704	0.1564	0	−0.2242	0.0015
	LA-C1A	10	SD	0.0068	0.0353	0	0.2295	0.0001
	LA-C1B*	11	mean	0.0733	0.1564	0.0117	1.1788	0.0037
	LA-C1B*	11	SD	0.0062	0.0334	0.0112	0.1605	0.0003
	p			NS	NS	*0.0038*	*0.0001*	*0.0001*

* The vk210b, vk210c and vk210d showed values more similar to OA than LA isolates and the carboxyl end was closed related to Asian isolates, and to avoid biased, they were not included in this group.
SD, standard deviation.
P, significance at 95% (two-sample t test).

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