Table 2 Prevalence of mutant alleles of pfcrt, pfmdr1 , dhfr and dhps genes among 108 Plasmodium falciparum in three sites in Yemen
From: Genetic diversity of Plasmodium falciparum and distribution of drug resistance haplotypes in Yemen
| Â | All | Taiz | Dhamar | Hodeidah |
|---|---|---|---|---|
pfcrt | n (%) | n (%) | n (%) | n (%) |
Alleles | Â | Â | Â | Â |
72S | 4 (4) | 0 | 0 | 4 (4) |
74I | 96 (89) | 55(50.9) | 29(26.9) | 12(11) |
75E | 96 (89) | 55(50.9) | 29(26.9) | 12(11) |
76T | 100 (93) | 55(50.9) | 29(26.9) | 16(14.8) |
Genotypes | Â | Â | Â | Â |
CVMNK | 8 (7) | 7(6.5) | 0 | 1(1) |
S VMNT | 4 (4) | 0 | 0 | 4 (4) |
CVIET | 96 (89) | 55(50.9) | 29(26.9) | 12(11) |
pfmdr1 | Â | Â | Â | Â |
Alleles | Â | Â | Â | Â |
86Y | 22 (20) | 18(16.7) | 3(3) | 1(1) |
184 F | 107 (99) | 62(57) | 28(25.9) | 17(15.7) |
1034C | 76 (70) | 44(40.7) | 20(18.5) | 12(11) |
1042D | 76 (70) | 44(40.7) | 20(18.5) | 12(11) |
1246Y | 0 | 0 | 0 | 0 |
Genotypes | Â | Â | Â | Â |
NYSND | 1 (1) | 0 | 1(1) | 0 |
NF SND | 23 (21) | 12(11) | 6(5.6) | 5(4.6) |
YF SND | 8 (8) | 6(5.6) | 2(2) | 0 |
NFCD D | 62 (57) | 32(29.6) | 19(17.6) | 11(10) |
YFCD D | 14 (13) | 12(11) | 1(1) | 1(1) |
dhfr | Â | Â | Â | Â |
Alleles | Â | Â | Â | Â |
51I | 58 (54) | 40(37) | 12(11) | 6(5.6) |
59R | 0 | 0 | 0 | 0 |
108 N | 58 (54) | 40(37) | 12(11) | 6(5.6) |
164 L | 0 | 0 | 0 | 0 |
Genotypes | Â | Â | Â | Â |
NCSI | 50 (46) | 22(20.4) | 17 | 11(10) |
I CN I | 58 (54) | 40(37) | 12(11) | 6(5.6) |
dhps | Â | Â | Â | Â |
Alleles | Â | Â | Â | Â |
436 F | 0 | 0 | 0 | 0 |
437G | 0 | 0 | 0 | 0 |
540E | 0 | 0 | 0 | 0 |
613S | 0 | 0 | 0 | 0 |
Genotypes | Â | Â | Â | Â |
SAKA | 108 (100) | 62 (57) | 29(26.9) | 17(15.7) |