Skip to main content

Table 2 Prevalence of mutant alleles of pfcrt, pfmdr1 , dhfr and dhps genes among 108 Plasmodium falciparum in three sites in Yemen

From: Genetic diversity of Plasmodium falciparum and distribution of drug resistance haplotypes in Yemen

  All Taiz Dhamar Hodeidah
pfcrt n (%) n (%) n (%) n (%)
Alleles     
72S 4 (4) 0 0 4 (4)
74I 96 (89) 55(50.9) 29(26.9) 12(11)
75E 96 (89) 55(50.9) 29(26.9) 12(11)
76T 100 (93) 55(50.9) 29(26.9) 16(14.8)
Genotypes     
CVMNK 8 (7) 7(6.5) 0 1(1)
S VMNT 4 (4) 0 0 4 (4)
CVIET 96 (89) 55(50.9) 29(26.9) 12(11)
pfmdr1     
Alleles     
86Y 22 (20) 18(16.7) 3(3) 1(1)
184 F 107 (99) 62(57) 28(25.9) 17(15.7)
1034C 76 (70) 44(40.7) 20(18.5) 12(11)
1042D 76 (70) 44(40.7) 20(18.5) 12(11)
1246Y 0 0 0 0
Genotypes     
NYSND 1 (1) 0 1(1) 0
NF SND 23 (21) 12(11) 6(5.6) 5(4.6)
YF SND 8 (8) 6(5.6) 2(2) 0
NFCD D 62 (57) 32(29.6) 19(17.6) 11(10)
YFCD D 14 (13) 12(11) 1(1) 1(1)
dhfr     
Alleles     
51I 58 (54) 40(37) 12(11) 6(5.6)
59R 0 0 0 0
108 N 58 (54) 40(37) 12(11) 6(5.6)
164 L 0 0 0 0
Genotypes     
NCSI 50 (46) 22(20.4) 17 11(10)
I CN I 58 (54) 40(37) 12(11) 6(5.6)
dhps     
Alleles     
436 F 0 0 0 0
437G 0 0 0 0
540E 0 0 0 0
613S 0 0 0 0
Genotypes     
SAKA 108 (100) 62 (57) 29(26.9) 17(15.7)
  1. n = number of isolates, mutated amino acids are bold and underlined.