Table 2 Prevalence of point mutation in dhfr and dhps gene in day 0 samples of patients enrolled for AS + SP therapeutic efficacy studies, central and eastern India, 2007 and 2010
Keonjhar (n = 71) | Ranchi (n = 53) | WGH (n = 25) | |||||
|---|---|---|---|---|---|---|---|
Genes | Codons | n M | %M | n M | % M | n M | %M |
dhfr | C59R | 59 38 | 64 | 53 36 | 68 | 18 18 | 100 |
S108N | 60 60 | 100 | 50 50 | 100 | 19 19 | 100 | |
I164L | 60 20 | 33 | 52 18 | 35 | 14 5 | 36 | |
dhps | K540E | 28 11 | 39 | 28 4 | 12 | 10 6 | 60 |
A581G | 28 8 | 28 | 28 5 | 14 | 15 0 | 0 | |